Adverse effects

Phencyclidine affects not only adults, but fetuses transplacentally and infants by transmission in breast milk. Undisclosed use by pregnant women is detectable in meconium.(3) Exposure to phencyclidine in utero is associated with reduced fetal growth, precipitous labours, and longer hospital stays. (4) Neurological consequences include poor attention, hypertonia, and depressed neonatal reflexes. (5) In vitro studies show that phencyclidine causes inhibited axon outgrowth, degeneration, and death in human fetal cerebral cortical neurones.(6)

Pathophysiological effects of phencyclidine toxicity in adults include hypertension, hyperthermia, opisthotonus, cardiac arrhythmia, seizure, and stroke. Phencyclidine is capable of provoking extreme muscular agitation. This condition of heightened muscular activity has been found to cause rhabdomyolysis and secondary renal failure in 2.5 per cent of users.(7) DSM-IV lists psychiatric effects of phencyclidine including intoxication, delirium, phencyclidine-induced psychotic, mood, and anxiety disorders, and phencyclidine abuse and dependence. A criterion for diagnosis is the emergence of the disorder within a month of drug use. While these disorders have been reported in anecdotes, a substantial clinical characterization exists for phencyclidine delirium and psychosis.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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