Absorption and metabolism

Taken orally the onset of action begins after 30 to 60 min, peaks at between 90 and 120 min with significant effects persisting for a further 3 to 6 h followed by a gradual 'come down' over the subsequent 6 to 12 h. The drug is primarily metabolized by demethylation by the hepatic cytochrome P-450 enzyme, debrisoquine hydroxylase coded for by CYP 2D6.(3) Two phenotypes predominate in the population with 9 per cent being 'poor metabolizers'. The consequence of metabolizer status on patterns of use and toxicity is as yet unknown. The drug may also be taken intranasally (snorted), rectally, and (rarely) intravenously.

Invisible Viagara

Invisible Viagara

You are about to discover the "little-known" techniques, tricks and "mind tools" that will show you how to easily "program" your body and mind to produce an instant, rock-hard erection. Learn how to enjoy all of the control, confidence and satisfaction that comes from knowing you can always "rise to the challenge" ... and never have to deal with embarrassment, apologies, shyness or performance anxiety in the bedroom, ever again.

Get My Free Ebook


Post a comment