Results

3.1. Rat Pituitary Tumors

In groups treated with MLT or CGP 52608 the BrDU mean labelling index was approximately 50% lower than in the respective control (Figure 1).

3.2. Colon 38 Murine Tumors in Vivo

MLT and CGP 52608 induced a significant decrease of the BrDU labelling indices vs controls. The effect was the strongest with 100 (g of MLT and with 10 (g of CGP 52608 (Figure 2).

Figure 2. Proliferation indices of Colon 38 adenocarcinomas in control (C), melatonin-treated (M) and CGP 52608-treated (CGp) mice. *p < 0.05, **p < 0.01, (according to (3)).

Figure 2. Proliferation indices of Colon 38 adenocarcinomas in control (C), melatonin-treated (M) and CGP 52608-treated (CGp) mice. *p < 0.05, **p < 0.01, (according to (3)).

3.3. Colon 38 Tumor Cells in Vitro

Both compounds inhibited the [3H]thymidine incorporation into DNA of Colon 38 cells. The effect of MLT was present in the concentration of 10-9 M and reaches the maximum at 10-7 M. CGP 5208 was slightly more potent than MLT but followed in principle the same concentration/effect curve as MLT, reaching a maximal inhibitory effect in concentration of 10-7 M.

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