Results

We found that MLT entrained all free-running rhythms measured in both of the experimental groups (see figure). Despite group differences in substance administration, the onset of running-wheel activity occured approximately at the same iN FUSION

DRINKING WATER REGIME

iN FUSION

LD 1212 Dim red light

Stop MLT

LD 1212 Dim red light

Stop MLT

Stop MLT

Figure 1. Representative double plotted running-wheel record of an infused rat (left panel), and of an animal submitted to a DWR (right panel). Successive days are plotted from top to bottom. Vertical bars indicate hour of infusion, or presence of water bottle for the animal kept under a DWR, respectively. Period of MLT administration is marked in black.

time in both groups, i.e. a few minutes after the beginning of MLT administration. The resulting phase angle between melatonin administration and onset of activity was very short for both groups. A free-running pattern in the measured rhythms was re-established when MLT was no longer present.

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