Discussion

I 150

E 200

5 100

We expected that manipulations during surgical removal of very large goitre might alter melatonin secretion via possible lesions of superior cervical ganglia during the surgery. Surprisingly, in all patients nocturnal melatonin concentrations were significantly higher after the operation than before the surgery. One of the possible explanations of this finding is that very large goitre may compress the superior cervical ganglia altering their function. It is also possible that the presence of goitre in some way affects melatonin secretion. In both our present studies and Kuzdak (1) decreased nocturnal melatonin concentrations were observed.

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Sleeping Solace

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