Conclusions

Patch-clamp technique is a recent laboratory technique that gives precise intimate understanding of many cellular mechanisms.

Time (sec)

Figure 2. Megakaryocyte in cell-attached configuration. Cytochalasin B solution is injected near megakaryocytes at 20 sec. After a later time of about 1 sec. Vm declines by 50% within 6 sec. The decline stops after 8.5 sec. and is followed by a second almost identical decline by 50% (from +36mv to +18mV) after 11.25 sec. Vm then proceeds nearly stable.

Figure 2. Megakaryocyte in cell-attached configuration. Cytochalasin B solution is injected near megakaryocytes at 20 sec. After a later time of about 1 sec. Vm declines by 50% within 6 sec. The decline stops after 8.5 sec. and is followed by a second almost identical decline by 50% (from +36mv to +18mV) after 11.25 sec. Vm then proceeds nearly stable.

Figure 3. Megakaryocyte in cell-attached configuration. The Cyt. B solution perfusion was followed by a sprightly 7.6 sec. duration (about 50% intense decline) before gradually stabilizing at the lower level.

Cytochalasins dramatically influence membrane properties of megakaryocytes: in some conditions complete block of many channels can be achieved.

These events could probably acquire some importance when applied to cancer cells, particularly some cells such as smooth cell lung carcinoma.

Future investigations will suggest the practical importance of Cytochalasins in the treatment of cancer.

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