Conclusions

Data presented here define morphologically the localization of 2-(125I)-iodomelatonin binding in the rat spleen and thymus. They demonstrate that the mela-tonin receptors are confined to subpopulations of lymphocytes at a different stage of maturity in the two structures studied. This finding suggests a selective mode of action of MLT in primary and secondary immune tissue and most probably reflects the difference in the observed changes on the glucocorticoid receptor characteristics in these organs. The demonstration of a glucocorticosteroid-dependent modulation of the glu-cocorticoid receptor binding capacity in the spleen, in reach of mature immunocom-petent cells, suggest that the pineal hormone might interact with corticosteroids to regulate immune function.

Sleeping Sanctuary

Sleeping Sanctuary

Salvation For The Sleep Deprived The Ultimate Guide To Sleeping, Napping, Resting And  Restoring Your Energy. Of the many things that we do just instinctively and do not give much  of a thought to, sleep is probably the most prominent one. Most of us sleep only because we have to. We sleep because we cannot stay awake all 24 hours in the day.

Get My Free Ebook


Post a comment