The structural framework and building fabric selected for the building can have considerable impact on clean-room design and its performance. In particular, the intrusion of structural features — such as expansion joints and structural columns or beams projecting into clean areas — should be avoided, if at all possible.

Equipment interfaces with the building fabric and finishes should be minimized where the integrity of the room is critical. This is most easily achieved by locating all nonessential equipment outside the clean room.

Where it is critical for equipment to be located in the clean room, then an acceptable alternative would be to build the equipment into the clean-room wall to allow operator access and loading to the front of the machine. The rear of the machine could be located in a utility area with the majority of the utility and service connection pipework restricted to this area.

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