Microorganisms are ubiquitous. In nature, potential sources of microorganisms are literally limitless. However, the huge array of potential sources of contamination is severely restricted when indoor pharmaceutical manufacturing environments are considered.

There are four major sources of microbiological contamination: air, water, materials and people.

A good working knowledge of how contamination may arise from these four sources, and how they can be controlled, is essential to the successful design and operation of microbiologically controlled environments and clean rooms.

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