H pylori and gastroesophageal reflux disease

Currently there is no evidence that H. pylori eradication worsen gastroesophageal reflux disease (GERD) in adults [41]. Limited data are also available in children. However, there is a theoretical risk, even though the data are conflicting, that long-term proton pump inhibitor (PPI) treatment could increase the development of H. pylori-associated atrophic gastritis and increase the risk of gastric cancer [42, 43]. Some experts recommend testing and eradicating H. pylori if the child or adolescent is undergoing endoscopy for GERD, but not for those with clinically diagnosed GERD [44].

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