Diagnosis of warts is made by the classic physical examination features, including absence of normal dermatoglyphics of the skin and presence of pinpoint areas of bleeding when the lesion is pared. These latter features distinguish warts from calluses. Because of the verrucous appearance microscopically, warts are often rough to the touch, distinguishing them from other viral skin conditions, such as molluscum. Furthermore, mollusca have central punctae [1, 3].
If the diagnosis is questioned one can perform a lesional skin biopsy for immunoperoxidase stains against HPV. In situ hybridization can also be done to detect specific viral types .
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