Myocardial Ischemia Basic Concepts

Constantinos Pantos*, Iordanis Mourouzis*, Dennis V. Cokkinos** 1. THE PATHOPHYSIOLOGY OF ISCHEMIA AND REPERFUSION INJURY 1.1. Cellular injury An imbalance between oxygen supply and demand due to compromised coronary flow results in myocardial ischemia. In theory, the process is very simple lack of adequate oxygen and metabolic substrates rapidly decreases the energy available to the cell and leads to cell injury that is of reversible or irreversible nature. In practice, the process is very...

Stress Signaling In Myocardial Ischemia

Myocardial Ischemic Preconditioning

Complex cell signaling pathways exist in the cell involved in growth, cell survival or cell death. Intracellular signaling is considered as an important transducer of both adaptive and maladaptive responses of the cell to stress. Signaling pathways are activated by ligand-receptor interaction or receptor independent stimuli such as mechanical stress, osmotic and oxidative stress or haemodynamic loading. Activation of intracellular signaling includes phosphorylations by tyrosine kinases and or...

From mechanisms to therapeutic potentials

Univeristy of Texas School of Medicine Houston, Texas, USA Dennis V. Cokkinos Prof, of Cardiology University of Athens Chairman Cardiology Dept. Onassis Cardiac Surgery Center Athens, Greece Director, Institute of Pathophysiology Constantinos Pantos Assistant Professor of Pharmadcology Depart. Of Pharmacology, Medical School University of Athens Athens, Greece Heinrich Taegtmeyer Professor of Medicine Co-Director, Division of Cardiology The University of Texas Houston Medical School Houston,...