Ultrastructure

Ductal adenocarcinoma cells are characterized by mucin granules in the apical cytoplasm, irregular microvilli on the lumi-nal surface, and a more or less polarised arrangement of the differently sized nuclei {359, 901, 1714}. The content of the mucin granules (0.4-2.0 |jm) varies from solid-electron dense to filamentous and punctate; often there is a dense

Fig. 10.06 Undifferentiated carcinoma with osteoclast-like giant cells. A The carcinoma is in the uncinate process and shows haemorrhagic necrosis. B There is marked cellular pleomorphism with scattered osteoclast-like giant cells and a well-differentiated ductal carcinoma component (left upper corner).

Fig. 10.06 Undifferentiated carcinoma with osteoclast-like giant cells. A The carcinoma is in the uncinate process and shows haemorrhagic necrosis. B There is marked cellular pleomorphism with scattered osteoclast-like giant cells and a well-differentiated ductal carcinoma component (left upper corner).

Fig. 10.07 Adenosquamous carcinoma. Note the glandular component on the left and the squamous differentiation on the right (arrowheads).

eccentric core. Some cells have features of gastric foveolar cells, showing granules with a punctate-cerebroid structure {1714}. Loss of tumour differentiation is characterized by loss of cell polarity, disappearance of a basal lamina, appearance of irregular luminal spaces, and loss of mucin granules {901}.

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