Precursor lesions

No documented precursor lesions for acinar cell carcinomas have been defined. Initial suggestions that so-called atypical acinar cell nodules may represent preneoplastic lesions of acinar cells have not been substantiated by later studies {1094}. Atypical acinar cell nodules occur either because of dilatation of the rough endoplasmic reticulum (resulting in reduced basophilia of the basal cytoplasm) or depletion of zymogen granules (resulting in reduced eosino-philia of the apical cytoplasm and an increase in nuclear:cytoplasmic ratio); these lesions are relatively common incidental findings in resected pancreases.

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