Endocrine tumours of the duodenum and upper jejunum usually form small (< 2 cm in diameter), grey, polypoid lesions within the submucosa with an intact or focally ulcerated overlying mucosa. However, some examples appear as infiltrative intramural nodules of rather large size (up to 5 cm in diameter). The tumours are multiple in about 13% of cases {208}. In a large series of 96 cases, the mean size was 1.8 cm (range, 0.2 to 5.0 cm) {208}. The mean size was 0.8 cm for gastrin-cell tumours {233}, 2.3 cm for somatostatin-cell tumours {1816} and 1.7 cm for ganglio-cytic paragangliomas {233}. Small cell carcinomas typically measure 2-3 cm, and present as focally ulcerated, or protuberant lesions {1870, 2196}.

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