Most colorectal carcinomas are located in the sigmoid colon and rectum, but there is evidence of changing distribution in recent years, with an increasing proportion of more proximal carcinomas

Fig. 6.05 Endoscopic features of (A) polypoid, (B) flat, slightly elevated and (C) flat adenoma.

{1928}. Molecular pathology has also shown site differences: tumours with high levels of microsatellite instability (MSI-H) or ras proto-oncogene mutations are more frequently located in the caecum, ascending colon and transverse colon. {842, 1563, 1897}.

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