Histopathology

The histological classification of tumours of the gallbladder and extrahepatic bile ducts is essentially similar to the previous WHO classification published in 1991 {1774} and to the classification adopted by the AFIP fascicle published in 2000 {35}.

Adenocarcinoma

Well to moderately differentiated adeno-carcinomas are the most common malignant epithelial tumours of the gallbladder and extrahepatic bile ducts. They are composed of short or long tubular glands lined by cells that vary in height from low cuboidal to tall columnar, superficially resembling biliary epithelium. Mucin is frequently present in the cells and glands. Rarely, the extracellular mucin may rscm Hi "

Fig. 9.05 Intestinal type adenocarcinoma. A Tubular glands similar to colonic adenocarcinoma. B Goblet cell type of adenocarcinoma. C Numerous serotonin containing cells in a neoplastic gland.

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