Gastrointestinal manifestations

Neoplasms of the digestive tract represent 7% of the tumours observed in Li-Fraumeni families. Most of these tumours are colorectal carcinoma, with a minority of stomach carcinomas. The malefemale ratio is 1.5 and the mean age at clinical manifestation is 45, which correspond to a relatively long latency period as compared to other types of cancers occurring in Li-Fraumeni families {1403}. Preferential familial occurrence of stomach cancer

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