Diagnostic criteria

In 1990, the International Collaborative Group on HNPCC (ICG-HNPCC) proposed a set of selection criteria to provide a basis for uniformity in collaborative studies {2003}. These criteria, referred to as Amsterdam Criteria I (ACI), have been widely used since then. Recently, the criteria have been revised to include the extracolonic cancers that are part of the syndrome. The new set of diagnostic criteria (ACII), is shown in Table 6.02 {2004}. They identify families that are very likely to represent HNPCC. On the other hand, they are not intended to serve as a guide to exclude suspected families from genetic counselling and mutation analysis.

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