Tumours of the Anal Canal
^ Although incidence rates are still low, there has been a signif-
^ <r icant increase in squamous cell carcinoma over the last 50 years. HIV infected homosexual men appear particularly at risk. HPV DNA is detectable in most anal squamous cell car cinomas.
^ ' Despite its short length, the anal canal produces a variety of tumour types reflecting its complex anatomic and histological structure. Squamous, glandular, transitional, and melanocytic components occur at this site, either alone, or in combination.
WHO histological classification of tumours of the anal canal
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