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Fig. 4.22 Intestinal T-cell lymphoma. Histological features of the most common variants. A Pleomorphic medium and large cells. B Anaplastic large cells. C Monomorphic small to medium cells.

irregular nuclei with small nucleoli and moderately wide, pale or sometimes clear cytoplasm {307}. Rare variants of ITL are composed predominantly of pleomorphic small cells or immunoblasts. Irrespective of morphology, the lymphoma cells often invade and destroy the overlying epithelium. Most frequently, the enterocytes of the upper and intermediate villous regions, or in cases of severe villous atrophy, the epithelium of the upper parts of the elongated crypts are the preferential targets of lymphoma cell attack. These features are best appreciated at the borders of ulcerated tumours. However, they may also be present as

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