Rr

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p value

Dry mouth Polyphagia/ polydipsia/ Polyuria Fatigue Sweating Constipation Numb limbs Low back pain

91.7 (1,587/1,730) 74.B (930/1,247) 1.2 (1.19-1.27) <0.0001

91.2 (1,4S4/1,B1B) S9.2 (1,B50/1,S49) S9.5 (1,359/1,518) 91.1 (1,327/1,45B) 91.S (1,305/1,427) S9.9 (1,418/1,578)

1.3 (1.23-1.33) 1.3 (1.23-1.33) 1.3 (1.22-1.32) 1.3 (1.21-1.30) 1.2 (1.19-1.28)

<0.0001 <0.0001 <0.0001 <0.0001 <0.0001 <0.0001

Glycemic Control

Most of the clinical trials showed that CHM recipes were effective in glycemic control [6]. Glycemic control was measured with surrogate parameters including fasting and postprandial blood glucose and glycosylated hemoglobin (HbA1c) [6]. Normalization of blood glucose was defined by a fasting blood glucose of <7.3mmol/l or a postprandial blood glucose of <8.2mmol/l [6]. Data from 78 controlled clinical trials showed the rate of normalizing blood glucose was higher in diabetic patients using CHM compared with control subjects (table 3) [6]. As a whole CHM appeared at least as effective as orthodox antidiabetic drugs in reducing blood glucose and HbA1c [6]. The blood glucose-lowering effects of CHM are probably related to enhanced insulin secretion [6] and improved insulin resistance [54].

Secondary Failure to Antidiabetic Drugs

Secondary failure to antidiabetic drugs substantially limits the effectiveness of Western drugs in the management of diabetes. Clinical trails have revealed that CHM and acupuncture in combination with Western medicine are effective in rescuing the secondary failure in patients with type-2 diabetes. Table 4 shows rates of improvement in glycemic control, as defined by a fasting plasma glucose of <8.2mmol/l plus symptom relief. The improvement rate was higher in patients (total number = 300) treated with integrated Chinese and Western medicine than those (total number = 296) receiving Western medicine alone in 5 controlled trials (RR = 1.1, 95% CI 1.02-1.18, p = 0.01) [55-59].

Table 3. Normalization of fasting blood glucose levels in 78 trials

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