Despite the advances made in the management of diabetes, people with uncontrolled hyperglycemia continue to suffer from dire complications. One of the most serious complications of diabetes is cardiovascular disease (CVD) . Although there are multiple potential causes for increased risk of premature CVD in diabetes, increased oxidative stress has emerged as an important therapeutic target to reduce the burden of this complication. Indeed, it is possible that overproduction of superoxide by the mitochondrial electron transport chain is the common link between the various pathways of gluco-toxicity . Thus, it is plausible that identifying agents that can reduce oxida-
tive load would reduce the risk of developing diabetic complications including CVD. Hence, the continued interest in antioxidant therapy in diabetes has generated a voluminous scientific literature. In this communication the potential mechanisms of increased oxidative load in diabetes will be reviewed and the currently available large trials of antioxidants in reducing disease burden will be critically evaluated. Finally the arguments in favor or against antioxidant supplementation will be discussed.
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