Insulin Resistance

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Many theories have sought to account for insulin resistance. The thrifty genotype hypothesis argues for gene selection against muscle proteolysis during an evolutionary history of recurring famine [25, 26]. In contrast, the thrifty phenotype hypothesis [27], which first described an association between low birth weight and insulin resistance, explains the link as a gesta-tional programming of the fetus in response to poor maternal nutrition. More

Age-standardized annual incidence of type 1 diabetes from 1968 to 1993

Age-standardized annual incidence of type 1 diabetes from 1968 to 1993

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