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3 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 Age at diagnosis (years)

Fig. 3. The relationship between body mass and age at onset of diabetes in an unselected group of children with type-1 diabetes; the fatter child develops type-1 diabetes younger - true acceleration [from 36].

weight in childhood of >120% is associated with a more than 2-fold greater risk of developing type-1 diabetes [48]. These observations provide important support for the hypothesis. They point to a central role for body mass, and by implication for insulin resistance in the development of type-1 as well as type-2 diabetes.

More importantly still, there are now two full length reports to indicate that, within a population with type-1 diabetes, the heaviest children develop type-1 diabetes the youngest - true acceleration [36, 39] (fig. 3).

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