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Currently the answer to the question of what is the optimal diet for glycemia and lipids is unknown. The best way to answer this question will be from randomized clinical trials comparing different diet plans, along the lines of the clinical trial of the four diets described above [15]. Such studies should be larger and have at least several years of follow-up. Most important (and most difficult) will be assuring that almost all participants remain under follow-up throughout the study.

In the opinion of the author, it is best to avoid overweight or obesity, and to limit saturated and trans fat, and high-fructose sweeteners. There is insufficient evidence to recommend the optimal balance between total fat and carbohydrate contents of the diet.

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