The Peroxiredoxin Repair Proteins

THOMAS J. J├ľNSSON AND W. TODD LOWTHER

Center for Structural Biology, Department of Biochemistry, Wake Forest University School of Medicine, Winston-Salem, North Carolina, 27157, USA

Abstract: Sulfiredoxin and sestrin are cysteine sulfinic acid reductases that selectively reduce or repair the hyperoxidized forms of typical 2-Cys peroxiredoxins within eukaryotes. As such these enzymes play key roles in the modulation of peroxide-mediated cell signaling and cellular defense mechanisms. The unique structure of sulfiredoxin facilitates access to the peroxiredoxin active site and novel sulfur chemistry

Keywords: Cysteine sulfinic acid, Retroreduction, Sulfiredoxin, Sestrin

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