Residues Conserved Among Specific Groups Of Prxs With Possible Roles In Catalysis

Based on sequence and structure considerations, Prxs can be divided into four (or arguably five) groups, designated here by their prototypic members (Table 1) (Hofmann et al., 2002; Dietz, 2003; Copley et al., 2004; Rouhier and Jacquot, 2005; see also Chapter 2). Additional specific residues conserved among members of each of the groups may have roles in peroxidatic or reductive cycles of these Prxs and are therefore pointed out here, although such roles remain only speculative at this point.

The most widespread group of Prxs, found across all kingdoms, is the group that includes the "typical 2-Cys" Prxs related to bacterial AhpC and mammalian Prxs I through IV, so named due to the absolute conservation of both perox-idatic and resolving Cys residues that participate in catalysis (with CR in the partner subunit of the dimer, within a C-terminal extension relative to the Trx

Table 1. Classification of Prxs based on sequence

and structure

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