Unlike the other major peroxide detoxification systems, namely catalases and peroxidases (which contain tightly or covalently bound heme) and true glutathione peroxidases (which have a selenocysteine at the active site), peroxiredoxins (Prxs; EC 188.8.131.52) rely on the cysteine sulfur at the active site as the catalytic center attacking the peroxyl -O-O- bond. Nonetheless, activation of this cysteine and the surrounding residues that support this function are sufficient, in at least some of the Prxs, to impart a level of catalytic efficiency that is on a par with those of the above enzymes (> 107M-1s-1) (Budde et al., 2003; Akerman and Müller, 2005; Parsonage et al., 2005). Initial studies of the biochemical functions of members of this family of antioxidant proteins focused on roles in protection of bacterial DNA from oxidant damage (Christman et al., 1985; Greenberg and Demple, 1988; Jacobson et al., 1989) and in protection of yeast glutamine synthetase from oxidative inactivation (Kim et al., 1988). As the recognition and understanding of
Was this article helpful?
Never before revealed. Home Detox - Step By Step Guide To Dextoxify The Body. Has too much late night behavior and partying got you feeling bad about yourself? Are you trying to lose weight but nothing is happening? Maybe you are just sick of all of the toxins that are in the air you breathe, the water you drink and the foods you eat. If so, then you need to do something about it. If you find yourself feeling bad about your health, there are ways that you can help your body right at home.