Acknowledgements

The author thanks Andy Karplus and Derek Parsonage for editorial suggestions. The research of the author is supported by grants from the National Institutes of Health (RO1 GM050389 and R21 CA112145 to Poole, and RO1 GM 072866 to W. Todd Lowther), from the National Science Foundation (MCB 0517343 to Jacquelyn Fetrow), and from a Joint Mathematical Biology Initiative from the Division of Mathematical Sciences-National Science Foundation and National Institute of General Medical Sciences (funded as RO1 GM075304 to Fetrow).

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