Use of immunoglobulin

Intravenous polyvalent immunoglobulin widely used as replacement therapy in immunodeficiencies, for Kawasaki disease to prevent the formation of coronary microaneurysms, and also as non-specific agent for reticuloendothelial blockade in immune cytopenias, chiefly (and usually unnecessarily) in childhood ITP. Can get immunoglobulin with particularly high titre against RSV, HZV and hepatitis B. Usually this is for intramuscular use only and should not be given IV due to risk of complement activation. IVIg has transmitted hepatitis C in the past due to poor virus inactivation procedures, so should not be used in trivial conditions.

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