Usage

• Given for both prophylaxis and treatment of CNS disease.

• May be used in addition to other CNS disease strategies such as high dose IV methotrexate or cranial irradiation.

• CNS involvement is detected by presence of blasts on CSF cytospin.

• The ONLY cytotoxic drugs used intrathecally are:

- Methotrexate.

- Cytosine arabinoside (ara-C).

- Hydrocortisone.

• All have strict upper dosage limits—follow the protocol.

Never use any other cytotoxic drugs for intrathecal injection—fatal consequences may ensue.

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