Tumour lysis syndrome TLS

Potentially life threatening metabolic derangement resulting from treatment-induced or spontaneous tumour necrosis causing renal, cardiac or neurological complications. Usually occurs in rapidly proliferating, highly chemosensitive neoplasms with high tumour load: leukaemias with high WBC counts (ALL >50 x 109/L; AML >100 x 109/L; CML blast crisis >100 x 109/L; CLL >200 x 109/L; PLL or ATLL >100 x 109/L) and high grade NHL (particularly Burkitt lymphoma or high serum LDH). May occur before or up to 5 days (usually 48-72h) after initiation of chemotherapy.

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