Transfusion reactions

Rapid temperature spike (>40°C) at start of transfusion indicates transfusion should be stopped (suggests acute intravascular haemolysis).

If slow rising temperature (<40°C), providing patient not acutely unwell, slow IVI. Fever often due to antibodies against WBCs (or to cytokines in platelet packs).

^ Immediate transfusion reaction

Intravascular haemolysis (—►haemoglobinaemia and haemoglobinuria). Usually due to anti-A or anti-B antibodies (in ABO mismatched transfusion). Symptoms occur in minutes/hours.

Immediate transfusion reaction or bacterial contamination of blood

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