Thrombophilia is a heritable or acquired disorder of the haemostatic mechanism predisposing to thrombosis, typically venous.

Arterial thrombosis is usually the result of atherosclerosis not blood hypercoagulability. Important exceptions are antiphospholipid activity (APL), paroxysmal nocturnal haemoglobinuria and rarely severe hyperho-mocysteinaemia. Virchov's triad of vessel, flow and blood is still a useful aide memoire for causes of thrombosis. Testing for heritable throm-bophilic is not indicated in patients with arterial thrombosis.

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