Stage 3 clinical symptoms

Marked by onset of symptoms, rising titre of circulating virus and decline in circulating CD4 T-cell count to <0.5 x 109/L. Wide variation in individual patient's rate of progression at this stage. A number of minor opportunistic infections are common: oral/genital candida, herpes zoster, oral leucoplakia. Lethargy, PUO and weight loss occur frequently. Deepening lymphopenia (CD4 <0.2 x 109/L) invariably present when opportunistic infection occurs. Persistent generalised lymphadenopathy is a condition where lymphadenopathy >1cm at 2 or more extra-inguinal sites persists for >3 months. It is a prodrome to severe immunodeficiency, opportunistic infection and neoplasia.

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