Specific conditions Factor XI

Deficiency more common in certain ethnic groups such as Ashkenazi Jews. Clinically of variable severity, often mild; even low factor levels may not produce symptoms whilst significant bleeding can occur with mild deficiency.


PT normal, APTT normal unless factor XI <40u/dL. Therefore necessary to measure factor XI level to make diagnosis in many cases.


Tranexamic acid and DDAVP for oral and dental surgery. Factor XI concentrates sometimes available. Otherwise, use virally-inactivated FFP.

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