Specific conditions Factor XI

Deficiency more common in certain ethnic groups such as Ashkenazi Jews. Clinically of variable severity, often mild; even low factor levels may not produce symptoms whilst significant bleeding can occur with mild deficiency.

Diagnosis

PT normal, APTT normal unless factor XI <40u/dL. Therefore necessary to measure factor XI level to make diagnosis in many cases.

Treatment

Tranexamic acid and DDAVP for oral and dental surgery. Factor XI concentrates sometimes available. Otherwise, use virally-inactivated FFP.

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