Risk factors for early progression of asymptomatic MM

Shorter time to progression associated with:

• Abnormal MRI (median <2 years vs. ~7 years).

• Suppression of uninvolved IgM to <3g/L.

• Urinary Bence Jones proteinuria >50mg/day.

These risk factors have no impact on survival after progression. Other risk factors for progression are high plasma cell labelling index; circulating plasma cells and karyotype abnormalities on conventional cytogenetics.

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