Proposed diagnostic criteria

• IgM monoclonal gammopathy of any concentration.

• BM infiltration by small lymphocytes, plasmacytoid cells and plasma cells.

• Intertrabecular pattern of BM infiltration.

• Immunophenotype: surface IgM+, CD5±, CD10-, CD19+, CD20+, CD22+, CD23-, CD25+, CD27+, FMC7+, CD103-, CD138-.

• WM may be divided into symptomatic WM and asymptomatic (smouldering) WM (~25%) by the presence or absence of symptoms attributable to either the IgM paraprotein (e.g. hyperviscosity or neuropathy) or tumour infiltration (BM failure or symptomatic organomegaly).

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