Prognostic factors

The most important prognostic factors predicting for achievement of remission and for subsequent relapse are:

1. Advancing patient age; <50 favourable; >60 unfavourable.

2. Presenting leucocyte count; <25 x 109/L favourable; >100 x 109/L unfavourable.

3. History of antecedent MDS or leukaemogenic therapy: unfavourable.

4. Presence of specific cytogenetic abnormalities (fflp)54).

5. FAB subtype: M3, M4Eo favourable; M0, M5a, M5b, M6, M7 unfavourable.

6. Failure to achieve CR with first cycle of induction therapy predicts for relapse.

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