Prognosis

• 70-80% of patients aged <60 years will achieve a CR with a modern regimen and good supportive care; more intensive induction and con- 157 solidation regimens reduce the risk of relapse.

• Relapse risk at 5 years in patients <60 with favourable risk cytogenetics is 29-42%; intermediate risk 39-60%; poor risk 68-90%.

• 50-60% of patients aged >60 years achieve CR with induction treatment (rate drops with each decade) but relapse occurs in 80-90%; a higher proportion have poor risk karyotype, previous myelodysplasia and co-morbidity; treatment-related morbidity and mortality is high.

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