Prognosis

Overall ~75% of adults with ALL achieve a CR with a modern regimen and good supportive care; more intensive induction and consolidation reduces relapse risk but adds toxicity; results in patients >50 are less good.

In contrast to the high cure rate in childhood ALL, leukaemia free survival in adult ALL in general is <30% at 5 years (patients > 50 years 10-20%). Leukaemia-free survival (LFS) after chemotherapy in patients without adverse risk factors is >50% whereas that for very high risk Ph/BCR-ABL+ ALL is <10%; hence the latter should have an allograft in CR1 if possible.

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