Problems with apheresis

General—patient anxiety, discomfort and boredom.

Citrate toxicity—parasthesiae, tremors, tetany.

Vascular and cardiac—poor venous access giving poor flow rates.

Extravasation, with haematoma at puncture sites, local vein thrombosis — during and after procedure, sepsis at puncture sites, hypo/hypervolaemia, vasovagal attacks, arrhythmias.

Metabolic and pharmacological—hypoalbuminaemia, hypoglycaemia, removal of drugs (plasma bound).

Allergic reactions—including anaphylaxis.

Drugs>75% bound: If drugs on the list below are due immediately prior to exchange, delay administration until after procedure.

Beta blockers

Propranolol

Timolol

Penbutolol

Ca2+ channel blockers

Diltiazem Nifedipine Verapamil

Anti-arrhythmics

Amiodarone Propofenone Quinidine

Digitoxin (Digoxin is OK) Diuretics

Furosemide (frusemide) Metolazone

Bendroflumethazide (bendrofluazide)

Diazoxide

Acetazolamide

Hypolipidaemics

Clofibrate

Gout drugs

Probenecid Sulfinpyrazone

Analgesics

NSAIDs (all)

Aspirin

Coproxamol

Benzodiazepines

Antidepressants

Antiepileptics

Carbamazepine Phenytoin Sodium valproate

Antipsychotics

Chlorpromazine

Haloperidol

Thioridazine

Antifungal agents

Amphotericin B Ketoconazole

Antihistamines

Chlorpheniramine

Antimalarials

Mepacrine Pyrimethamine

Antibiotics

Cloxacillin Flucloxacillin Penicillin V Sulphonamide Doxycycline

Anti-TB

Rifampicin

Anticoagulants

Heparin Warfarin

Thyroid Drugs

Thyroxine

Triiodothyronine

Propylthiouracil

Oestrogens and progestogens

Hypoglycaemics

Tolbutamide

Glipizide

Gliclazide

Glibenclamide

Chlorpropamide

0 0

Post a comment