Pretransfusion testing

Maternal and neonatal samples should be taken and tested as follows:

Maternal samples

1. ABO and Rh group.

2. Antibody screen.

Infant samples

3. ABO and Rh group.

5. Antibody screen (if maternal sample unavailable).

Note: Provided no atypical antibodies are present in maternal or infant serum and the DAT on the infant's cells is -ve, a conventional cross-match is unnecessary. Small volume replacement transfusions can be given repeatedly during the first 4 months of life without further serological testing. Transfusion centres may specifically designate a supply of low anti-A, B titre group O Rh (D) -ve blood for use in neonatal transfusions. After the first 4 months, compatibility testing should conform to requirements for adults.

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