Polycythaemia vera PV

Erythrocytosis is defined as increase in total red cell mass (RCM). It is suspected by finding a raised haematocrit (Hct) (packed cell volume, PCV). The term 'polycythaemia' is widely used synonymously but lacks precision and can lead to confusion. Polycythaemia vera (PV) is a neoplastic clonal disorder of the BM stem cell causing excessive proliferation of the ery-throid, myeloid and megakaryocyte lineages and carrying a risk of thrombotic complications. Persistent elevation of Hct >0.48 in adult female and >0.51 in adult male is abnormal (Note: Hct can be raised with a normal RCM if plasma volume is reduced).

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