Platelet counts in children are essentially the same as adults as far as the lower limit is concerned, but there is greater volatility at the upper end and infants tend to produce high counts (>5 00 x 109/L) as part of an acute phase reaction more frequently. There is a statistically significant fall in the upper limit (95th centile) from 4 years onwards from around 500 to reach 350-400 by the end of childhood.

Cord blood platelets are less reactive to aggregating agents in vitro and have other features of hypofunction compared with mature platelets.

0 0

Post a comment