Pathophysiology

Neonatal RBCs have 4 sensitivity to oxidative stress due to altered enzyme activity, and are more liable to be destroyed by altered physical conditions, mechanical factors, toxins and drugs than adult RBC Infection acquired in utero post-natally is a common cause of mild to moderate haemolytic anaemia. The mechanism is multifactorial, and includes 4 retic-uloendothelial activity and microangiopathic damage. Drug-induced haemolysis and Heinz body formation is occasionally noted as a transient phenomenon in normal neonatal RBCs as a result of chemical or drug toxicity but is much more often seen when there is an underlying RBC defect such as G6PD deficiency.

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