Pathophysiology

In AL amyloidosis the fibrillar deposits are composed of the variable regions of immunoglobulin light chains (VL) in association with gly-cosaminoglycans and amyloid P component derived from the normal plasma protein serum amyloid P (SAP) component. More commonly l light chains. Unique amino acid insertions may render the proteins amy-loidogenic. Without treatment deposits progressively accumulate in viscera notably kidneys, heart, liver and peripheral nervous system causing increasingly severe dysfunction. Under favourable circumstances, further amyloid deposition can be prevented, deposits can regress and improvement in organ dysfunction can occur.

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

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