Other causes of haemosiderosis

Dietary iron overload may also occur as a result of chronic over-ingestion of iron-containing traditional home-brewed fermented maize beverages peculiar to sub-Saharan Africa, which overwhelms physiological controls on iron absorption. Iron stores may >50g and iron is initially deposited in both hepatocytes and Kupffer cells but when cirrhosis develops, accumulates in the pancreas, heart and other organs. Over-ingestion of medicinal iron may possibly have a similar though less dramatic effect but is certainly harmful to patients with iron-loading disorders. The excessive iron absorption seen in patients with chronic liver disease is associated with accumulation in Kupffer cells rather than hepatic parenchyma. Rare congenital defects associated with iron overload have been reported.

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