1. Anti-bacterial prophylaxis—consider use of ciprofloxacin 250mg bd PO from day 7—>21 of each course.

2. Anti-fungal prophylaxis: Patients with no history of fungal reactivation should perform nystatin suspension 1mL qds mouthcare from day

7—>21 of each course, taught symptoms of oral and genital thrush and supplied with fluconazole 200mg to be taken daily for 7d in the event of thrush.

3. Patients with previous history of suspected fungal infection with a mould-type organism e.g. Aspergillus—give itraconazole capsules 400mg daily or oral liquid 2.5mg/kg bd throughout treatment.

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